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. 2009 Mar 16;4(3):e4849. doi: 10.1371/journal.pone.0004849

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Gemenetzidis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Alignment of genome-wide LOH profiles of non-transformed (FOXM1B) and FOXM1B-transformed SVpgC2a clones (SVFN1-8). Black lines indicate LOH at a given SNP loci. Histogram (red bars) displays consensus regions of LOH across the 8 SVFN transformed clones. (B) Magnified and detail chromosomal view of the three consensus micro-loci within chromosome 4, 10 and 18 with a list of genes located within each locus as indicated. Uniparental disomy (UPD, blue); copy number gain (CN gain, red); copy number loss (CN loss, green); consensus LOH loci in at least 6 SVFN clones (pink).