Table 1. Blood glucose selectively controls ß-cell proliferation in islets of diabetic mice.

	naïve				diabetic
	BrdU	-label: 1 d a	BrdU	-label: 3 d	BrdU	-label: 1 d	BrdU	-label: 3 d
	(n)	BrdU+ (%)b	(n)	BrdU+ (%)	(n)	BrdU+ (%)	(n)	BrdU+ (%)
IF c	2	0.4	2	0.5	2	1.8	4	5.5
FCM	4	0.2	7	0.1	8d	2.3	14d	5.7

^aBrdU-labeling by injection (i.p.), either 1 day (1 d), or on 3 consecutive days (3 d) before pancreas harvest.

^bpercentage of BrdU+ cells among insulin+ cells.

^cimmunofluorescence microscopy scoring of ≧ 47 individual islets or small endocrine clusters of at least 2 spatially separated pancreas sections per mouse. Total β-cells scored: (naïve mice: 1,830; diabetic mice: 944)

^dmice analyzed include islets in Figure 3, and Table 2, respectively.