Figure 2. NBCCS fibroblasts in dermal equivalents over-express MMP1, MMP3 and FGF7.

The levels of secreted MMP1, MMP3 and FGF7 were determined by ELISA in the supernatants of the dermal equivalents used for the microarray assay. Results were set to 1 for the protein levels in the supernatant of the dermal equivalent with control (CTRL) fibroblast strain 1. The protein level in control strains is represented with grey histogram and with black histogram in NBCCS strains. The average MMPs and FGF7 levels in the supernatants of control (NBCCS) dermal equivalents are indicated with a plain (dotted) line. The ratios between the average protein levels in NBCCS and in control fibroblasts are indicated (arrow).