Table 1. More than 2.1 fold up-regulated genes in the two NBCCS pools*.
| Primary Sequence Name | Accession Number | missense pool | nonsense pool | NBCCS | |||
| Fold Increase | p-value | Fold Increase | p-value | Fold Increase | p-value | ||
| MMP3 | NM_002422 | 19.7421 | 0 | 13.0139 | 0 | 15.931 | 0 |
| ALDH1A3 | NM_000693 | 5.92 | 0 | 10.883 | 0 | 6.799 | 1.61E-34 |
| KCNJ8 | NM_004982 | 12.2448 | 0 | 10.1035 | 5.14E-32 | 11.282 | 0 |
| MMP1 | NM_002421 | 8.4122 | 0 | 7.8028 | 0 | 8.174 | 0 |
| CLIC6 | NM_053277 | 18.5676 | 1.72E-35 | 7.711 | 3.54E-13 | 17.042 | 3.64E-31 |
| COL11A1 | NM_080629 | 9.7967 | 9.06E-22 | 5.4611 | 4.28E-14 | 10.146 | 2.21E-12 |
| IL13RA2 | NM_000640 | 8.9084 | 0 | 4.6296 | 2.00E-19 | 6.822 | 1.52E-23 |
| DHRS3 | NM_004753 | 4.3342 | 0 | 3.7553 | 3.85E-33 | 4.409 | 0 |
| APBB1IP | NM_019043 | 4.6804 | 0 | 3.7532 | 2.47E-40 | 4.209 | 0 |
| MASP1 | NM_139125 | 3.2252 | 1.34E-21 | 3.421 | 3.33E-18 | 3.245 | 4.03E-21 |
| BX537788 | BX537788 | 4.3842 | 9.63E-37 | 3.408 | 1.22E-15 | 4.197 | 4.80E-19 |
| SPOCK1 | NM_004598 | 3.1251 | 0 | 3.3341 | 0 | 3.376 | 0 |
| ANGPTL4 | NM_139314 | 7.5098 | 0 | 3.1122 | 0 | 4.353 | 1.07E-10 |
| GHR | NM_000163 | 4.5814 | 9.60E-26 | 3.0934 | 4.03E-06 | 4.065 | 5.44E-16 |
| KCTD15 | NM_024076 | 3.0865 | 1.44E-21 | 3.0498 | 1.42E-19 | 3.069 | 0 |
| AI476245 | AI476245 | 5.1206 | 0 | 3.0481 | 3.41E-17 | 4.46 | 4.73E-33 |
| AF264625 | AF264625 | 2.8355 | 7.77E-28 | 2.8518 | 2.37E-25 | 2.918 | 0 |
| SMOC2 | NM_022138 | 5.5702 | 6.90E-20 | 2.788 | 4.85E-06 | 5.133 | 2.20E-13 |
| FLJ14834 | NM_032849 | 5.8414 | 0 | 2.7641 | 6.60E-32 | 3.872 | 1.26E-11 |
| MGC42157 | BC030111 | 2.9857 | 0 | 2.759 | 1.59E-22 | 2.986 | 0 |
| PTGIS | NM_000961 | 2.8252 | 5.37E-22 | 2.7335 | 2.82E-23 | 2.882 | 1.10E-42 |
| NANOS1 | NM_199461 | 3.609 | 3.75E-13 | 2.6956 | 5.74E-12 | 2.696 | 5.75E-12 |
| DPP3 | NM_130443 | 2.6339 | 8.64E-18 | 2.6929 | 3.39E-17 | 2.663 | 5.37E-38 |
| CXCL12 | NM_199168 | 2.8062 | 1.10E-34 | 2.5629 | 5.33E-25 | 2.695 | 7.25E-38 |
| MGST1 | NM_145791 | 3.9293 | 0 | 2.5332 | 2.55E-24 | 2.903 | 1.35E-13 |
| SNCA | NM_007308 | 3.0297 | 3.71E-30 | 2.5018 | 7.41E-09 | 2.853 | 1.17E-26 |
| PRL | NM_000948 | 5.4189 | 0 | 2.484 | 2.42E-15 | 4.168 | 1.90E-11 |
| ADARB1 | NM_015833 | 2.2018 | 6.96E-29 | 2.4494 | 6.38E-38 | 2.333 | 0 |
| AKR1C1 | NM_001353 | 2.8523 | 5.59E-37 | 2.4218 | 7.18E-21 | 2.53 | 1.65E-29 |
| CCRL1 | NM_178445 | 2.3757 | 1.12E-18 | 2.4162 | 1.81E-26 | 2.484 | 0 |
| BC035260 | BC035260 | 2.1041 | 3.96E-12 | 2.4093 | 6.50E-09 | 2.189 | 2.68E-21 |
| AA417913 | AA417913 | 2.37 | 3.52E-19 | 2.409 | 1.49E-29 | 2.429 | 5.32E-38 |
| TFPI2 | AK129833 | 6.1688 | 4.05E-40 | 2.4071 | 1.13E-06 | 5.176 | 3.85E-11 |
| GPC6 | BX640888 | 3.4137 | 7.47E-36 | 2.405 | 7.60E-21 | 2.627 | 2.08E-22 |
| DSCR1 | NM_004414 | 2.2516 | 1.42E-10 | 2.4037 | 1.24E-11 | 2.322 | 3.13E-22 |
| STEAP1 | NM_012449 | 2.9091 | 0 | 2.3808 | 7.46E-35 | 2.545 | 8.36E-35 |
| AKR1C3 | NM_003739 | 2.3671 | 8.04E-21 | 2.3569 | 7.55E-24 | 2.362 | 0 |
| AKR1C1 | NM_001353 | 2.8883 | 0 | 2.3474 | 1.23E-39 | 2.682 | 4.93E-13 |
| CMTM1 | NM_181289 | 2.3129 | 3.71E-31 | 2.3448 | 1.11E-25 | 2.368 | 0 |
| EXOSC6 | NM_058219 | 2.2792 | 0 | 2.3187 | 1.12E-44 | 2.275 | 0 |
| HSPA5BP1 | NM_017870 | 2.8592 | 5.23E-18 | 2.2717 | 4.12E-15 | 2.354 | 1.88E-30 |
| CDON | AK022986 | 2.6989 | 2.02E-19 | 2.2717 | 1.60E-08 | 2.452 | 5.46E-14 |
| STEAP2 | NM_152999 | 2.8101 | 7.94E-37 | 2.2325 | 1.10E-09 | 2.714 | 0 |
| PPAP2A | NM_176895 | 3.5108 | 6.87E-38 | 2.23 | 1.83E-35 | 2.49 | 3.14E-16 |
| STEAP1 | NM_012449 | 2.8538 | 0 | 2.2024 | 2.10E-39 | 2.392 | 3.50E-23 |
| CPM | NM_001874 | 3.715 | 0 | 2.1577 | 1.14E-25 | 3.001 | 3.31E-11 |
| NR4A3 | NM_173200 | 4.2339 | 0 | 2.1442 | 3.44E-11 | 3.204 | 2.21E-10 |
| CA12 | NM_001218 | 2.9836 | 0 | 2.1333 | 0 | 2.344 | 6.78E-19 |
| PCSK5 | NM_006200 | 3.4846 | 0 | 2.1278 | 1.36E-09 | 2.602 | 2.16E-08 |
| WISP2 | NM_003881 | 2.5103 | 1.30E-23 | 2.1266 | 6.04E-18 | 2.185 | 2.91E-35 |
| SAA1 | NM_000331 | 3.048 | 0 | 2.1112 | 1.25E-21 | 2.343 | 4.35E-16 |
*
List of the 51 genes, with their OMIM accession number associated, whose mRNA levels were increased more than 2.1 fold in the missense and the nonsense pools. In the two NBCCS pools, for each gene, the fold increase compared to the control pool and its p-value are mentioned. The average NBCCS level was determined by combining the two NBCCS pools in the Resolver software. The p-value “0” is due to rounding of p-values strictly inferior to 7.01*10−45.