Figure 2. Application of Protocol II to human microarray data.

Each histogram is the distribution of the repeated 10-fold cross-validation AUC estimates for each dataset under the null hypothesis “there is no signal present in the data” (as computed by 400 random outcome value permutations). The red line in each graph is the observed value of AUC estimated by the repeated 10-fold cross-validation on the original data. AUC and p-values are shown for each dataset in the embedded table. Bold p-values indicate that the null hypothesis is rejected at the 0.05 level in these datasets.