Figure 6.
Sir2 is not required for WldS-mediated protection of severed axons, and membrane-tethered WldS fails to suppress axon degeneration. (A) UAS-Sir2RNAi was driven in OR22a+ ORNs with OR22a-Gal4 in the presence or absence of WldS, and axons were assayed 15 d after injury. (B) The requirements for Sir2 in WldS-mediated axon protection were assayed 15 d after injury in WldS-expressing axons and WldS axons that lacked sir2 (sir24.5/sir25.26). WldS, n = 10; Sir2−/− + WldS, n = 6. Error bars represent SEM.