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. 2009 Feb 23;184(4):541–554. doi: 10.1083/jcb.200806139

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© 2009 Mizoguchi et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Schematic representation of osteoclast niche. Osteoclasts differentiate from monocyte/macrophage lineage cells through two sequential cell cycle–related events. Cell cycle–arrested QuOPs are the committed precursors of osteoclasts. Osteoclast precursors proliferate and differentiate into QuOPs in hemopoietic tissues. QuOPs reach osteoclast niches prepared by osteoblasts. QuOPs differentiate into osteoclasts without cell cycle progression in response to all the stimuli that induce osteoclast formation. Osteoblasts may play a pivotal role in maintaining QuOPs for a long period in an undifferentiated state.