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. 2009 Mar 19;4(3):e4936. doi: 10.1371/journal.pone.0004936

Figure 3. Microarray and Cluster Analysis.

Figure 3

In A) Genes were filtered out on the “present” call (P-call) generated by MAS 5.0 leaving 12,536 genes. A 2-way ANOVA test performed on log10-transformed data comparing control with IAD detects the significantly expressed genes. Changes in gene expression in the IAD patients were evaluated at 3 levels of significance (p<0.05, p<0.01, p<0.001) for patients grouped by MMSE values and summarized in the chart below, B). We used the p<0.01 analysis gene list for further study. In C), cluster analysis shows relative mRNA message in controls (black bar) and IAD patients (green bar) with increased expression (green to red) or decreased expression (red to green). Blue line above the heatmap encompasses patients with gene profiles transitional between control and IAD. See Table S2 for genes lists with gene name, symbol and fold change.