Table 2. Nervous system function and development genes upregulated with ≥1.4 fold change in IAD.

GENE SYMBOL	GENE NAME	Fold change
CHRM3	cholinergic receptor, muscarinic 3	2.3
GRIA2	glutamate receptor, ionotropic, AMPA 2 (GluR2)	2.3
NRGN	neurogranin (protein kinase C substrate, RC3)	1.9
SLC1A2	solute carrier family 1 , member2 (GLT2)	1.9
HOMER1	Homer homolog 1 (Drosophila)	1.7
EPHA4	EPH receptor A4	1.8
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	1.8
THY1	Thy-1 cell surface antigen	1.8
NRXN1	neurexin 1	1.7
GPR51	G protein-coupled receptor 51	1.7
CAMK2B	Calcium/calmodulin-dependant protein kinase II beta	1.7
RAB14	RAB14 member RAS oncogene family	1.6
APOE	apolipoprotein E	1.5
SV2A	synaptic vesicle glycoprotein 2A	1.5
GAP43	growth associated protein 43	1.5
SCN1B	sodium channel, voltage-gated, type I, beta	1.5
ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	1.5
PRKCZ	protein kinase C, zeta	1.5
LPPR4	Plasticity related gene	1.5
PUM1	Pumilio homolog 1 (Drosophila)	1.4

The Ingenuity® category ‘Nervous System Development and Function’ contains many genes involved in synaptic function, including those that are identified by EASE analysis. Many of these genes encode putative mRNA binding sites for proteins which regulate translation (see Table S5 for information on 3′UTR regulatory sequences).