Table 1. Serum chemistry from mice on standard chow and HFD.
Fed glucose (mg/dl) | Fasting glucose (mg/dl) | Insulin (pmol/L) | Resistin (ng/ml) | Leptin (ng/mL) | Free fatty acids (mM) | Triglyceride (mg/dl) | |
Standard Chow | |||||||
Mstn+/+ | 142±5 | 102±7 | 544±98 | 3.78±0.14 | 24.60±1.32 | 0.323±0.040 | 65.3±5.2 |
Mstn−/− | 140±9 | 87±5 | 103±34 | 3.48±0.13 | 1.96±0.57‡‡ | 0.219±0.022 | 41.1±3.7** |
HFD | |||||||
Mstn+/+ | 143±5 | 126±6† | 884±96† | 4.79±0.29* | 28.34±1.72 | 0.300±0.020 | 51.8±5.6 |
Mstn−/− | 140±7 | 109±8* | 177±50‡‡ | 3.72±0.26 | 17.28±3.40† | 0.252±0.034 | 40.3±3.3 |
Standard Chow | |||||||
Non-tg | 140±5 | 95±3 | 332±110 | 3.36±0.08 | 10.47±2.20 | 0.479±0.069 | 61.7±5.4 |
Muscle-DN | 124±4 | 81±4 | 60±9 | 3.10±0.20 | 0.34±0.20 | 0.222±0.026†† | 35.7±2.5** |
HFD | |||||||
Non-tg | 136±4 | 113±10* | 676±107* | 4.84±0.50† | 18.12±3.56 | 0.431±0.052 | 44.5±4.5* |
Muscle-DN | 124±5 | 89±6 | 182±50†† | 3.59±0.14 | 2.35±0.99** | 0.271±0.037 | 33.6±3.9 |
Standard Chow | |||||||
Non-tg. | 142±5 | 83±3 | 346±91 | 3.79±0.18 | 10.06±5.81 | 0.378±0.059 | 52.5±8.7 |
Fat-DN | 146±7 | 104±10 | 136±21 | 4.82±0.12 | 16.37±3.92 | 0.181±0.017†† | 44.4±5.1 |
HFD | |||||||
Non-tg | 180±12‡ | 144±6‡ | 652±120* | 5.94±0.31‡ | 24.42±4.23† | 0.286±0.034 | 46.6±9.8 |
Fat-DN | 167±5* | 115±7 | 513±139† | 8.10±0.76‡,‡‡ | 23.39±4.48 | 0.199±0.019 | 40.5±3.3 |
Data are expressed as mean±SEM of 5–17 per group.
P<0.05.
P<0.01.
P<0.001 vs. same genotype on standard chow.
P<0.05.
P<0.01.
P<0.001 vs. control on the same diet.
Non-tg, non-transgenic controls.