Table 1. Serum chemistry from mice on standard chow and HFD.

	Fed glucose (mg/dl)	Fasting glucose (mg/dl)	Insulin (pmol/L)	Resistin (ng/ml)	Leptin (ng/mL)	Free fatty acids (mM)	Triglyceride (mg/dl)
Standard Chow
Mstn+/+	142±5	102±7	544±98	3.78±0.14	24.60±1.32	0.323±0.040	65.3±5.2
Mstn−/−	140±9	87±5	103±34	3.48±0.13	1.96±0.57‡‡	0.219±0.022	41.1±3.7**
HFD
Mstn+/+	143±5	126±6†	884±96†	4.79±0.29*	28.34±1.72	0.300±0.020	51.8±5.6
Mstn−/−	140±7	109±8*	177±50‡‡	3.72±0.26	17.28±3.40†	0.252±0.034	40.3±3.3
Standard Chow
Non-tg	140±5	95±3	332±110	3.36±0.08	10.47±2.20	0.479±0.069	61.7±5.4
Muscle-DN	124±4	81±4	60±9	3.10±0.20	0.34±0.20	0.222±0.026††	35.7±2.5**
HFD
Non-tg	136±4	113±10*	676±107*	4.84±0.50†	18.12±3.56	0.431±0.052	44.5±4.5*
Muscle-DN	124±5	89±6	182±50††	3.59±0.14	2.35±0.99**	0.271±0.037	33.6±3.9
Standard Chow
Non-tg.	142±5	83±3	346±91	3.79±0.18	10.06±5.81	0.378±0.059	52.5±8.7
Fat-DN	146±7	104±10	136±21	4.82±0.12	16.37±3.92	0.181±0.017††	44.4±5.1
HFD
Non-tg	180±12‡	144±6‡	652±120*	5.94±0.31‡	24.42±4.23†	0.286±0.034	46.6±9.8
Fat-DN	167±5*	115±7	513±139†	8.10±0.76‡,‡‡	23.39±4.48	0.199±0.019	40.5±3.3

Data are expressed as mean±SEM of 5–17 per group.

^* P<0.05.

^† P<0.01.

^‡ P<0.001 vs. same genotype on standard chow.

^** P<0.05.

^†† P<0.01.

^‡‡ P<0.001 vs. control on the same diet.

Non-tg, non-transgenic controls.