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. Author manuscript; available in PMC: 2009 Mar 11.
Published in final edited form as: Mol Cell. 2008 Apr 25;30(2):137–144. doi: 10.1016/j.molcel.2008.02.022

Table 1. Mutator Effects of the pol3-L612M Allele.

ura3 Forward Mutation Rates

URA3 Orientation OR1 OR2

Genotype Mutation Rate (× 10−7)
(95% CI)
Fold Increase Mutation Rate (× 10−7)
(95% CI)
Fold Increase
WT 0.34 (0.25–0.74) 1.0 0.48 (0.38–0.78) 1.0

msh2Δ 24 (12–38) 71 29 (19–62) 60

pol3-L612M 2.7 (1.9–7.3) 7.9 3.3 (2.9–3.9) 6.9

pol3-L612M msh2Δ 560 (500–750) 1600 510 (360–790) 1100