Table 1. Mutator Effects of the pol3-L612M Allele.
ura3 Forward Mutation Rates | ||||
---|---|---|---|---|
URA3 Orientation | OR1 | OR2 | ||
Genotype | Mutation Rate (× 10−7) (95% CI) |
Fold Increase | Mutation Rate (× 10−7) (95% CI) |
Fold Increase |
WT | 0.34 (0.25–0.74) | 1.0 | 0.48 (0.38–0.78) | 1.0 |
msh2Δ | 24 (12–38) | 71 | 29 (19–62) | 60 |
pol3-L612M | 2.7 (1.9–7.3) | 7.9 | 3.3 (2.9–3.9) | 6.9 |
pol3-L612M msh2Δ | 560 (500–750) | 1600 | 510 (360–790) | 1100 |