. Author manuscript; available in PMC: 2009 Mar 11.

Published in final edited form as: Gastroenterology. 2008 Nov 1;136(3):1048–1059. doi: 10.1053/j.gastro.2008.10.027

Table I.

NKT cells suppress cholestatic liver injury

Mouse strain	Pre-treatment	BDL	Plasma ALT activity (U/L)
Wild-type	Untreated	−	30 ± 8
	Untreated	sham	42 ± 11
	Untreated	+	305 ± 90^a
Jα18^−/−	Untreated	+	704 ± 94
	Adoptive transfer	+	391 ± 100^b

NOTE: Groups of mice were untreated or inoculated i.v. with 5 ×10⁵ purified NKT cells (adoptive transfer) at 18 hours prior to surgery. Plasma was collected on day 3 following BDL or sham operations, and ALT levels were quantified. Data are derived from two or more experiments and plasma samples obtained from ≥6 mice.

Significantly greater than non-operated or sham-operated control animals; P<0.001.

Significantly less than Jα18−/ − mice not administered NKT cells: P=0.049.