Table II.

Neutrophil depletion reduces cholestatic liver injury in iNKT cell-deficient mice

Mouse strain	Pre-treatment	Plasma ALT (U/L)	Neutrophils (% NPCs)
Jα18−/−	normal IgG	778 ± 160	52.3 ± 15.4
	1A8 mAb	264 ± 110a	17.1 ± 11.4b
Wild-type	normal IgG	332 ± 73	NDc
	1A8 mAb	204 ± 84	ND

NOTE: Groups of 6 mice were pre-treated with the mAb indicated or an equivalent concentration of normal rat IgG; the common bile duct was ligated and divided. Plasma was collected and ALT levels were quantified on day 3 post-surgery. Values are representative of two or more experiments. Significantly less than Jα18−/− mice administered normal rat IgG:

^aP<0.001;

^bP=0.012.

^cND, not determined