Table 2.
Results of multivariate multinomial logistic regression (RRR with 95%CI). Correlates of increased APRI in a cohort of HIV-infected individuals, adjusted for age and self-reported race. Reference category is APRI<0.4. n=1358
| Participant Characteristic | Unadjusted RRR for RRR for 0.4<APRI<1.5 |
Adjusted RRR for 0.4<APRI<1.5 |
Unadjusted RRR for APRI>1.5 |
Adjusted RRR for APRI>1.5 |
|---|---|---|---|---|
| Gender | ||||
| Female | 1.00 | 1.00 | 1.00 | 1.00 |
| Male | 1.51 (1.18-1.93) | 1.61 (1.22-2.14) | 1.35 (0.93-1.94) | 1.45 (0.95-2.20) |
| HCV ab+ | ||||
| No | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 4.48 (3.50-5.72) | 3.32 (2.35-4.68) | 7.52 (5.03-11.25) | 4.73 (2.71-8.25) |
| HBsAg+ | ||||
| No | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 1.64 (1.07-2.23)) | 1.66 (1.04-2.67) | 2.41 (1.38-4.20) | 2.60 (1.40-4.83) |
| HIV transmission category IDU? | ||||
| No | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 3.65 (2.87-4.66) | 1.74 (1.23-2.45) | 5.82 (3.98-8.50) | 2.29 (1.35--3.89) |
| CD4 nadir | ||||
| ≤50 | 1.00 | 1.00 | 1.00 | 1.00 |
| 51-200 | 0.87 (0.65-1.15) | 0.80 (0.59-1.10) | 1.10 (0.73-1.67) | 1.02 (0.65-1.62) |
| 201-350 | 0.66 (0.48-0.91) | 0.62 (0.44-0.89) | 0.85 (0.53-1.37) | 0.80 (0.48-1.34) |
| >350 | 0.60 (0.41-0.86) | 0.44 (0.29-0.67) | 0.38 (0.19-0.75) | 0.24 (0.11-0.51) |
| HIV RNA<400 | ||||
| No | 1.00 | 1.00 | 1.00 | 1.00 |
| Yes | 0.63 (0.50-0.79) | 0.65 (0.50-0.85) | 0.43 (0.30-0.62) | 0.45 (0.30-0.68) |
| Alcohol category | ||||
| 0 (no consumption) | 1.00 | 1.00 | 1.00 | 1.00 |
| 1 (non-hazardous) | 0.91 (0.69-1.21) | 0.99 (0.72-1.36) | 0.87 (0.56-1.35) | 0.95 (0.59-1.55) |
| 2 (hazardous) | 1.54 (1.04-2.27) | 1.78 (1.15-2.76) | 2.00 (1.18-3.37) | 2.30 (1.26-4.17) |
Abbreviations: RRR, relative risk ratio; 95%CI, 95% confidence interval; APRI, aspartate aminotransferase to platelet ratio index; HCV-Ab, Hepatitis C antibody; HBSAg, hepatitis B surface antigen; IDU, injection drug use.
Alcohol categories: 0, no alcohol consumption; 1, no more than 14 drinks per week and no more than 4 drinks per occasion for men or no more than 7 drinks per week and no more than 3 drinks per occasion for women; 2, more than 14 drinks per week or more than 4 drinks per occasion for men or more than 7 drinks per week or more than 3 drinks per occasion for women.