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. Author manuscript; available in PMC: 2009 Mar 11.
Published in final edited form as: Biol Psychiatry. 2007 Oct 26;63(9):858–863. doi: 10.1016/j.biopsych.2007.08.019

Figure 1.

Figure 1

fMRI statistical maps showing that pretreatment responsivity to fearful versus neutral faces is positively correlated in the left rACC (red) and negatively correlated in the left amygdala (blue) with subjects' drop in HAM-A scores after 8 weeks of treatment with venlafaxine. R=right, L=left. Images thresholded at p = .05, corrected.FvN=fear versus neutral contrast in the rACC(A) and amygdala(B). Y axis=drop in HAM-A scores after 8 weeks of treatment (i.e., pretreatment minus posttreatment score); X axis=fMRI percent signal change. Higher rACC reactivity and lower amygdala reactivity predict a greater drop in reported anxiety. Results are similar for the fear versus happy (FvH) contrast(C, D) but not the happy versus neutral (HvN) contrast (E, F) (data presented from the FvN contrast locus), showing that these effects are specific to fearful faces. Axes same as in (A) and (B). (G) rACC and amygdala responses to fearful versus neutral faces are negatively correlated showing that the subjects with higher rACC signal tend to be the subjects with lower amygdala signal. Both axes are fMRI percent signal change. fMRI, functional magnetic resonance imaging; HAM-A, Hamilton Anxiety Rating Scale; rACC, rostral anterior cingulate cortex.