Figure 2.

Roles of PPARγ in the collecting system of the kidney. (a) Expression of PPARγ is confined to the distal collecting system (labeled with green) including connective tubules (cn) and collective ducts (ct). (b) Hematoxylin and esoin stained cross-sections of the kidney medulla showing numerous collective ducts (ct). (c) Fluorescent PPARγ immunostaining in the same region of the kidney. (d) Oil red-O stained sections of the distal tubules (dt) showing severe lipid accumulation in type 2 diabetic (db/db) mice. (e) Summary of PPARγ functions in the collective system.