Table A1.
Grade 3 and Higher Toxicities That Occurred With ≥ 10% Incidence Within a Block
| Toxicity | Block 1 (n = 124)
|
Block 2 (n = 91)
|
Block 3 (n = 102)
|
|||
|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | |
| Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection) | 50 | 40.3 | 26 | 28.6 | 45 | 44.1 |
| Fibrinogen | 40 | 32.3 | 0 | 0 | 0 | 0 |
| Hemoglobin | 78 | 62.9 | 59 | 64.8 | 79 | 77.5 |
| Hyperglycemia | 15 | 12.1 | 0 | 0 | 0 | 0 |
| Hypokalemia | 0 | 0 | 0 | 0 | 17 | 16.7 |
| Infection (documented clinically or microbiologically) with grade 3 or 4 neutropenia | 24 | 19.4 | 10 | 11.0 | 36 | 35.3 |
| Leukocytes (total WBC) | 30 | 24.2 | 13 | 14.3 | 20 | 19.6 |
| Neutrophils/granulocytes (ANC/AGC) | 121 | 97.6 | 88 | 96.7 | 101 | 99.0 |
| Platelets | 99 | 79.8 | 59 | 64.8 | 98 | 96.1 |
| ALT | 18 | 14.5 | 0 | 0 | 0 | 0 |
| Transfusion | ||||||
| Platelets | 93 | 75.0 | 41 | 45.1 | 98 | 96.1 |
| pRBCs | 95 | 76.6 | 68 | 74.7 | 92 | 90.2 |
Abbreviations: ANC, absolute neutrophil count; AGC, absolute granulocyte count; pRBCs, packed red blood cells.