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. Author manuscript; available in PMC: 2009 Mar 11.
Published in final edited form as: Biol Chem. 2008 Aug;389(8):993–1006. doi: 10.1515/BC.2008.124

Figure 3. In vivo administration of CA074Me, E64d or Ac-LVK-CHO reduces brain Aβ and CTFβ in the guinea pig.

Figure 3

E64d or CA074Me were administered by constant icv infusion into guinea pig brains by ALZET minipumps for 7 days or 30 days. Brain extracts were prepared and total Aβ (Aβ40 and Aβ42) were measured by ELISA assays.

(a) E64d reduces brain Aβ levels. E64d treatment for 7 or 30 days reduced the total Aβ by 31% and 55% relative to control, respectively (diagonal striped bars). Results are shown as mean ± SEM (pg/mg protein), with * indicating a significant difference from controls (p < 0.05, student’s t-test).

(b) CA074Me reduces brain Aβ levels. In vivo CA074Me treatment for 7 or 30 days reduced total Aβ by 57% and 62% relative to control, respectively (solid bars). After 7 days of treatment, CA074Me significantly reduced total Aβ. Data are shown as mean ± SEM (pg/mg protein), with statistical significance with * indicating a significant difference from controls (p < 0.05, student’s t-test).