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. Author manuscript; available in PMC: 2009 Mar 11.
Published in final edited form as: Cell Tissue Res. 2008 Nov 5;334(3):339–358. doi: 10.1007/s00441-008-0709-2

Fig. 1. Lmx1a expression undergoes dynamic changes in wildtype and mutants.

Fig. 1

A. In the E10.5 wildtype, expression is in all but the neurosensory precursor epithelium (NSP). B., C. Compare the wildtype endolymphatic duct (ED) with its vestigial mutant counterpart. D. Lmx1b is not expressed in the E10.5 ear (dotted line), but is strongly expressed in the hindbrain (in and out of focus labeling top left). E., F. In the E11.5 mutant, Lmx1a expression is incompletely segregated to the lateral/posterior cochlea (CO) and no trace of an endolymphatic duct is apparent. G. At E12.5, expression is becoming confined to the ED, lateral cochlea and the non-sensory saccule. H.-J. By E14.5, expression centers on the ED and radiates to more-or-less constricted spacer epithelia between sensory epithelial territories. Most conspicuous of these is the ductus reunions (DR). K. At E18.5, cochlear expression is localized to the outer spiral sulcus (OSS). Melanocytes are conspicuous in the adjacent stria vascularis (SV). L.-N. In wildtype mice, the organ of Corti (OCin N.) is entirely free of Lmx1a expression. However, mutant Lmx1a mRNA is broadly expressed throughout the basal turn (L,M). All whole ears are oriented as in A. Scale bars are 100 µm.