Table 2.

Cancer Recurrence and Mortality According to Body Mass Index

Recurrence and Mortality	Body Mass Index (kg/m2)					P*
	< 21	21-24.9	25-29.9	30-34.9	≥ 35
Disease-free survival†
No. of events	27	90	117	85	50
No. at risk	68	258	369	236	112
Unadjusted HR	1.13	Reference	0.86	1.00	1.18	.86
Unadjusted 95% CI	0.73 to 1.73		0.66 to 1.14	0.75 to 1.35	0.84 to 1.67
Adjusted HR‡	1.35	Reference	0.81	1.00	1.24
Adjusted 95% CI	0.86 to 2.13		0.59 to 1.11	0.72 to 1.40	0.84 to 1.83
Recurrence-free survival§
No. of events	23	83	104	79	49
No. at risk	68	258	369	236	112
Unadjusted HR	1.04	Reference	0.83	1.01	1.25	.65
Unadjusted 95% CI	0.65 to 1.64		0.62 to 1.11	0.74 to 1.38	0.88 to 1.78
Adjusted HR‡	1.22	Reference	0.75	0.97	1.27
Adjusted 95% CI	0.75 to 1.98		0.54 to 1.03	0.69 to 1.37	0.85 to 1.89
Overall mortality
No. of events	17	69	85	60	30
No. at risk	68	258	369	236	112
Unadjusted HR	0.91	Reference	0.84	0.93	0.88	.63
Unadjusted 95% CI	0.53 to 1.54		0.61 to 1.15	0.66 to 1.31	0.58 to 1.36
Adjusted HR‡	1.07	Reference	0.72	0.90	0.87
Adjusted 95% CI	0.61 to 1.87		0.50 to 1.03	0.61 to 1.34	0.54 to 1.42

Abbreviation: HR, hazard ratio.

^*Likelihood-ratio test (two-sided) for the body mass index term for continuous functional form: BMI + BMI².

^†Measured by cancer recurrence or death from any cause.

^‡Analyses were adjusted for sex, age, depth of invasion through bowel wall (T1-2 v T3-4), number of positive lymph nodes (1-3 v ≥ 4), presence of clinical perforation at time of surgery, presence of bowel obstruction at time of surgery, baseline performance status (0 v 1-2), treatment arm, weight change between first and second questionnaire, smoking status at time of second questionnaire (current, past, and never), and physical activity level.

^§Measured by cancer recurrence.