Table 3.

Pharmacokinetic Parameters of Rapamycin

Dose (mg)	Day	Pharmacokinetic Parameters
		Tmax (hours)			Cmax (ng/mL)			Vz/F (L)			Cls/F (L/h)			T1/2,z (hours)			AUC (ng · h/mL)			Css,min (ng/mL)
		Median	Range	No.	Mean	SD	No.	Mean	SD	No.	Mean	SD	No.	Mean	SD	No.	Mean	SD	No.	Mean	SD	No.
2	1	2.02	1.98-3.00	4	7.0	2.7*	4	354.7	371.5	2	29.0	30.6	2	11.13	3.15	4	65.3	69.1*	2	6.6	6.6	4
2	28	2.00	1.07-4.05	3	9.2	1.8*	3	277.5	473.2	2	16.3	0.8	3	11.23		1	122.7	5.6*	3
3	1	2.00	1.00-3.92	3	8.2	2.4*	3	231.9		1	17.5		1	9.20	16.57	2	171.6*		1	7.3	2.8	3
3	28	1.93	1.00-2.00	3	19.3	5.6*	3	541.5	228.4	3	13.1	5.1	3	29.04	9.92	3	254.1	98.7*	3
6	1	2.00	1.00-6.00	9	21.3	8.1*	9	356.1	33.8	3	22.3	2.6	3	14.46	3.11	9	272.1	33.2*	3	12.7	7.1	9
6	28	1.98	1.00-5.12	9	27.6	15.0*	9	562.5	367.6	3	20.5	14.7	9	28.52	8.19	3	445.2	318.1*	9
9	1	2.00	1.00-2.08	5	28.4	13.1*	5	173.8		1	38.2		1	11.44	6.05	4	235.7*		1	23.6	7.4	5
9	28	2.00	4.00	2	37.9	50.8*	2	217.3	395.4	2	12.3	15.2	2	12.21	18.05	2	592.7	729.5*	2
All	1	2.00	1.00-6.00	21				314.3	80.6	7	26.0	7.1	7	12.95*	3.99	19
	28	2.00	1.00-8.08		18			467.6	240.8	10	17.7	11.1	17	23.79*	10.03	9

NOTE. When n ≤ 2, individual values are reported. AUC_inf is reported for all dose levels for day 1; AUC_{0-24 hours} is reported for all dose levels for day 28.

Abbreviations: AUC, area under the concentration-time curve; C_max, maximal plasma concentration; Cl_s/F, apparent systemic clearance; C_ss,min, steady state plasma concentration at trough; NR, not reportable; T_max, time of the maximal plasma concentration; T_1/2,z, terminal half-life; V_z/F, apparent volume of distribution; SD, standard deviation.

^*P < .05 using a Wilcoxon matched pairs signed-rank test.