Skip to main content
. 2008 Sep 1;26(25):4172–4179. doi: 10.1200/JCO.2008.16.2347

Table A1.

Pharmacokinetic/Pharmacodynamic Correlations

End Point Day 28 Pearson's Correlation Coefficient
Cmax AUC0-8 hours AUC0-24 hours
SUV −0.071 −0.088 0.036
    P .779 .729 .888
Day 2 PBMC phospho-P70 variation −0.095 −0.204 −0.226
    P .795 .572 .529
Average PBMC phospho-P70 variation −0.056 −0.091 −0.147
    P .871 .790 .666
Day 28 skin phospho-P70 variation 0.388 0.368 0.350
    P .171 .196 .220
Day 28 skin phospho-S6 variation –.633 –.590 –.553
    P .02 .034 .05
Day 28 skin phospho-4EBP1 variation −0.271 −0.296 −0.362
    P .371 .326 .224

NOTE. Of the explored PD end points, the only one that showed a solid correlation with the PK profile was the variation (defined as % normalized to baseline) in skin phospho-S6 activation (indicated by boldfacing), where exposure was inversely correlated to phosphorylation levels.

Abbreviations: AUC, area under the concentration-time curve; Cmax, maximal plasma concentration; PBMC, peripheral-blood mononuclear cell; SUV, standard uptake value.