Table A1.
End Point | Day 28 Pearson's Correlation Coefficient
|
||
---|---|---|---|
Cmax | AUC0-8 hours | AUC0-24 hours | |
SUV | −0.071 | −0.088 | 0.036 |
P | .779 | .729 | .888 |
Day 2 PBMC phospho-P70 variation | −0.095 | −0.204 | −0.226 |
P | .795 | .572 | .529 |
Average PBMC phospho-P70 variation | −0.056 | −0.091 | −0.147 |
P | .871 | .790 | .666 |
Day 28 skin phospho-P70 variation | 0.388 | 0.368 | 0.350 |
P | .171 | .196 | .220 |
Day 28 skin phospho-S6 variation | –.633 | –.590 | –.553 |
P | .02 | .034 | .05 |
Day 28 skin phospho-4EBP1 variation | −0.271 | −0.296 | −0.362 |
P | .371 | .326 | .224 |
NOTE. Of the explored PD end points, the only one that showed a solid correlation with the PK profile was the variation (defined as % normalized to baseline) in skin phospho-S6 activation (indicated by boldfacing), where exposure was inversely correlated to phosphorylation levels.
Abbreviations: AUC, area under the concentration-time curve; Cmax, maximal plasma concentration; PBMC, peripheral-blood mononuclear cell; SUV, standard uptake value.