Table 2.
Characteristics of Patients With Lung Cancer and Survival Rates
| Predictor | No. of Patients | % | No. of Patients Dead | Survival Time (months)
|
Hazard Ratio | 95% CI | P (χ2) | |
|---|---|---|---|---|---|---|---|---|
| Median | 95% CI | |||||||
| Sex | ||||||||
| Male | 1,047 | 66 | 1,001 | 10.5 | 9.9 to 11.1 | |||
| Female | 530 | 34 | 490 | 12.1 | 11.0 to 13.4 | 0.84 | 0.75 to 0.94 | .0024 |
| Race | ||||||||
| White | 1,331 | 84 | 1,252 | 11.1 | 10.6 to 11.8 | |||
| Black | 168 | 11 | 164 | 10.2 | 8.6 to 12.2 | 1.17 | 0.99 to 1.39 | |
| Hispanic | 40 | 3 | 40 | 9.2 | 6.8 to 13.3 | 1.13 | 0.82 to 1.56 | |
| Other | 38 | 2 | 35 | 9.4 | 7.4 to 14.6 | 1.09 | 0.78 to 1.54 | .2800 |
| Age, years* | ||||||||
| < 50 | 180 | 11 | 171 | 10.0 | 8.5 to 11.0 | |||
| 50-59 | 425 | 27 | 401 | 11.1 | 10.3 to 12.6 | 0.89 | 0.74 to 1.07 | |
| 60-69 | 619 | 39 | 585 | 11.8 | 11.1 to 12.8 | 0.83 | 0.70 to 0.99 | |
| 70+ | 353 | 22 | 334 | 9.5 | 8.4 to 10.9 | 0.93 | 0.77 to 1.12 | .1567 |
| Marital status | ||||||||
| Single | 101 | 6 | 100 | 9.5 | 8.1 to 10.7 | |||
| Married | 1,047 | 66 | 977 | 11.2 | 10.4 to 12.2 | 0.81 | 0.66 to 1.00 | |
| Separated | 39 | 2 | 38 | 12.1 | 8.0 to 14.0 | 0.94 | 0.64 to 1.37 | |
| Divorced | 225 | 14 | 220 | 10.6 | 9.7 to 11.6 | 0.95 | 0.75 to 1.21 | |
| Widowed | 165 | 10 | 156 | 11.7 | 9.5 to 13.5 | 0.81 | 0.62 to 1.04 | .1060 |
| PS | ||||||||
| 0 | 609 | 39 | 556 | 14.7 | 13.6 to 16.1 | |||
| 1 | 820 | 52 | 789 | 9.8 | 9.0 to 10.4 | 1.47 | 1.31 to 1.64 | |
| 2 | 148 | 9 | 146 | 6.1 | 3.9 to 7.5 | 2.52 | 2.06 to 3.08 | < .0001 |
| Chest pain | ||||||||
| No | 1,073 | 68 | 1,006 | 11.8 | 11.0 to 12.7 | |||
| Yes | 504 | 32 | 485 | 9.5 | 8.4 to 10.5 | 1.27 | 1.13 to 1.42 | < .0001 |
| Dyspnea | ||||||||
| No | 802 | 51 | 740 | 12.3 | 11.3 to 13.3 | |||
| Yes | 775 | 49 | 751 | 10.0 | 9.4 to 10.7 | 1.26 | 1.14 to 1.40 | < .0001 |
| Bone pain | ||||||||
| No | 1,325 | 84 | 1,244 | 11.6 | 10.9 to 12.3 | |||
| Yes | 252 | 16 | 247 | 7.6 | 6.7 to 9.2 | 1.28 | 1.11 to 1.48 | .0006 |
| CNS symptoms | ||||||||
| No | 1,513 | 96 | 1,431 | 11.0 | 10.5 to 11.7 | |||
| Yes | 64 | 4 | 60 | 8.5 | 6.0 to 10.9 | 1.24 | 0.95 to 1.62 | .1123 |
| Duration of symptoms, months | ||||||||
| < 3 | 1,050 | 67 | 993 | 10.9 | 10.3 to 11.6 | |||
| 3-6 | 361 | 23 | 342 | 10.7 | 9.0 to 11.8 | 1.00 | 0.88 to 1.13 | |
| > 6 | 166 | 11 | 156 | 11.8 | 10.3 to 13.9 | 0.93 | 0.78 to 1.10 | .6938 |
| Weight loss, % | ||||||||
| None to < 5 | 1,169 | 74 | 1,095 | 12.6 | 11.7 to 13.5 | |||
| ≥ 5 | 408 | 26 | 396 | 7.4 | 6.5 to 7.8 | 1.55 | 1.37 to 1.75 | < .0001 |
| Liver metastases | ||||||||
| No | 1,353 | 86 | 1,271 | 11.8 | 11.1 to 12.7 | |||
| Yes | 224 | 14 | 220 | 6.4 | 5.8 to 7.4 | 1.49 | 1.27 to 1.75 | < .0001 |
| Adrenal metastases | ||||||||
| No | 1,418 | 90 | 1,335 | 11.5 | 11.0 to 12.2 | |||
| Yes | 159 | 10 | 156 | 6.4 | 5.7 to 7.6 | 1.29 | 1.08 to 1.55 | .0055 |
| Bone metastases | ||||||||
| No | 1,285 | 81 | 1,202 | 12.2 | 11.4 to 12.9 | |||
| Yes | 292 | 19 | 289 | 7.4 | 6.2 to 8.0 | 1.34 | 1.16 to 1.54 | < .0001 |
| Brain | ||||||||
| No | 1,555 | 99 | 1,470 | 11.0 | 10.5 to 11.6 | |||
| Yes | 22 | 1 | 21 | 6.5 | 3.2 to 13.6 | 1.24 | 0.78 to 1.98 | .3644 |
| WBC ≥ 8.7 × 103 | ||||||||
| No | 768 | 49 | 718 | 12.2 | 11.4 to 13.6 | |||
| Yes | 809 | 51 | 773 | 9.9 | 9.0 to 10.6 | 1.20 | 1.08 to 1.33 | .0005 |
| Hemoglobin ≥ 14.6 g/dL | ||||||||
| No | 1,271 | 81 | 1,206 | 10.4 | 9.8 to 11.0 | |||
| Yes | 306 | 19 | 285 | 13.4 | 12.2 to 14.6 | 0.80 | 0.70 to 0.92 | .0014 |
| Platelets ≥ 400,000 | ||||||||
| No | 1,138 | 72 | 1,072 | 12.2 | 11.5 to 13.3 | |||
| Yes | 437 | 28 | 417 | 8.5 | 7.8 to 9.3 | 1.34 | 1.19 to 1.51 | < .0001 |
| Alkaline phosphatase ≥ 100 U/mL | ||||||||
| No | 853 | 54 | 798 | 12.6 | 11.6 to 13.6 | |||
| Yes | 721 | 46 | 690 | 9.1 | 8.5 to 10.2 | 1.24 | 1.11 to 1.38 | < .0001 |
| Education | ||||||||
| Grades 1-8 | 206 | 13 | 196 | 11.3 | 9.7 to 13.9 | |||
| Grades 9-11 | 284 | 18 | 273 | 11.0 | 9.8 to 12.9 | 1.04 | 0.86 to 1.26 | |
| High school graduate | 524 | 33 | 496 | 10.5 | 9.5 to 11.4 | 1.06 | 0.90 to 1.26 | |
| Some college | 355 | 23 | 333 | 11.3 | 10.3 to 12.6 | 0.94 | 0.78 to 1.12 | |
| College degree | 208 | 13 | 193 | 11.1 | 10.0 to 13.1 | 1.00 | 0.81 to 1.23 | .5141 |
Abbreviation: PS, performance status.
*
Age at enrollment onto clinical trial.