Table 4.
Multivariable Cox Model Predictive of Survival As a Function of Clinical Predictors
| Variable | df | Parameter Estimate | SE | χ2 | P (χ2) | Hazard Ratio | 95% CI |
|---|---|---|---|---|---|---|---|
| Female | 1 | −0.17131 | 0.06073 | 7.9579 | .0048 | 0.843 | 0.748 to 0.949 |
| PS: 1 v 0 | 1 | 0.28039 | 0.05973 | 22.0387 | < .0001 | 1.324 | 1.177 to 1.488 |
| PS: 2 v 0 | 1 | 0.66433 | 0.10804 | 37.8117 | < .0001 | 1.943 | 1.572 to 2.401 |
| Married | 1 | −0.12290 | 0.05821 | 4.4578 | .0347 | 0.884 | 0.789 to 0.991 |
| Dyspnea | 1 | 0.16148 | 0.05522 | 8.5526 | .0035 | 1.175 | 1.055 to 1.310 |
| Weight loss | 1 | 0.18400 | 0.06575 | 7.8308 | .0051 | 1.202 | 1.057 to 1.367 |
| Liver metastases | 1 | 0.27325 | 0.08402 | 10.5765 | .0011 | 1.314 | 1.115 to 1.549 |
| Bone metastases | 1 | 0.30869 | 0.07287 | 17.9454 | < .0001 | 1.362 | 1.180 to 1.571 |
| Hemoglobin ≥ 14.6 g/dL | 1 | −0.15781 | 0.07118 | 4.9157 | .0266 | 0.854 | 0.743 to 0.982 |
| Platelets ≥ 400,000 | 1 | 0.13783 | 0.06214 | 4.9196 | .0266 | 1.148 | 1.016 to 1.296 |
| Adrenal metastases among NSCLC | 1 | 0.36004 | 0.09861 | 13.3302 | .0003 | 1.433 | 1.181 to 1.739 |
| Alkaline phosphatase > 100 U/mL among NSCLC | 1 | 0.17243 | 0.06385 | 7.2932 | .0069 | 1.188 | 1.048 to 1.347 |
| WBC ≥ 8.7 × 103 among extensive/advanced patients | 1 | 0.19829 | 0.06865 | 8.3430 | .0039 | 1.219 | 1.066 to 1.395 |
Abbreviations: PS, performance status; NSCLC, non–small-cell lung cancer.