Table 3.
Drug-Related* Adverse Events of Grade 3 to 5 or Any Grade Occurring in More Than 20% of Patients
| Toxicity | Any Grade
|
Grade 3
|
Grade 4
|
Grade 5
|
||||
|---|---|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | No. of Patients | % | No. of Patients | % | |
| Cough | 19 | 73.1 | 1 | 3.8 | 0 | 0 | 0 | 0 |
| Dyspnea | 17 | 65.4 | 3 | 11.5 | 3 | 11.5 | 0 | 0 |
| Hypoxia | 10 | 38.5 | 8 | 30.8 | 0 | 0 | 1† | 3.8 |
| Pneumonitis/infiltrates | 7 | 26.9 | 4 | 15.4 | 0 | 0 | 1† | 3.8 |
| Hemoptysis | 7 | 26.9 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other pulmonary | 6 | 23.1 | 0 | 0 | 1 | 3.8 | 0 | 0 |
| Anemia | 15 | 57.7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fatigue | 12 | 46.2 | 2 | 7.7 | 0 | 0 | 0 | 0 |
| Fever | 12 | 46.2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rigors/chills | 11 | 42.3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 6 | 23.1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Myalgias | 6 | 23.1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hyponatremia | 5 | 19.2 | 1 | 3.8 | 0 | 0 | 0 | 0 |
| Chest pain | 5 | 19.2 | 1 | 3.8 | 0 | 0 | 0 | 0 |
| Arthralgias | 4 | 15.4 | 1 | 3.8 | 0 | 0 | 0 | 0 |
| Lymphopenia | 1 | 3.8 | 1 | 3.8 | 0 | 0 | 0 | 0 |
*
Considered possibly, probably, or definitely drug related by the investigator.
†
Occurred in the same patient.