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. Author manuscript; available in PMC: 2009 Nov 11.
Published in final edited form as: Biochemistry. 2008 Oct 18;47(45):11735–11749. doi: 10.1021/bi801625b

Table 4.

Structure, NPI, and KD's of top hits discovered in HTS against BasE.

Compound # Structure NPI (%)a KD (μM)b
23 graphic file with name nihms86525t1.jpg 99 0.078 ± 0.007
24 graphic file with name nihms86525t2.jpg 80 2.86 ± 0.24
25 graphic file with name nihms86525t3.jpg 78 4.22 ± 0.28
26 graphic file with name nihms86525t4.jpg 76 4.95 ± 0.50
27 graphic file with name nihms86525t5.jpg 58 14.1 ± 1.6
28 graphic file with name nihms86525t6.jpg 61 15.0 ± 1.0
29 graphic file with name nihms86525t7.jpg 42 20.2 ± 1.3
30 graphic file with name nihms86525t8.jpg 44 22.1 ± 1.4
31 graphic file with name nihms86525t9.jpg 59 23.8 ± 1.8
32 graphic file with name nihms86525t10.jpg 85 28.6 ± 2.1
33 graphic file with name nihms86525t11.jpg 40 29.3 ± 3.1
a

The NPI values determined from HTS data.

b

KD determined by a FP competitive binding assay in triplicate. Values represent the mean and standard error.