Small intestine and colon histology. In the small intestine note normal histology (A–B, 10× and 40× magnification, respectively). In the colon note ulceration (C black arrow), congestion (C white arrow, 20× magnification), crypt abscesses (D black arrow), goblet cell depletion (D white arrow, 10× magnification), loss of crypts (E black arrow), goblet cell depletion, infiltration of inflammatory cells, regenerative hyperplasia of crypt epithelium, and flattening of crypt lining (E white arrow, 10× magnification), lymphocytic aggregates in the submocusa extending to the mucosa (F black arrow) and loss of crypts (F white arrow, 10× magnification).