Table I.
Classification of pure red cell aplasia*.
| Inherited |
| Diamond Blackfan anaemia |
| Acquired PRCA |
| Primary |
| Autoimmune [includes Transient Erythroblastopenia ofChildhood (TEC)] |
| Pearson syndrome (sideroblastic anaemia with vacuolatederythroid precursors) |
| Preleukemic |
| Idiopathic |
| Secondary, associated with: |
| Thymoma |
| Hematological malignancies |
| Chronic lymphocytic leukemia |
| Large granular lymphocyte leukemia |
| Chronic myelocytic leukemia |
| Acute lymphoblastic leukemia |
| Hodgkin lymphoma |
| Non-Hodgkin lymphomas |
| Multiple myeloma |
| Waldenström macroglobulinemia |
| Myelofibrosis with myeloid metaplasia |
| Essential thrombocythemia |
| Solid Tumours |
| Carcinoma of the stomach |
| Adenocarcinoma of the breast |
| Adenocarcinoma of bile duct |
| Squamous cell carcinoma of the lung |
| Epidermoid carcinoma of the skin |
| Carcinoma of the thyroid |
| Renal cell carcinoma |
| Carcinoma of unknown primary site |
| Kaposi sarcoma |
| Infections |
| Human B19 parvovirus |
| Human immunodeficiency virus (HIV) |
| T-cell leukemia-lymphoma virus |
| Epstein-Barr virus (infectious mononucleosis) |
| Viral hepatitis |
| Mumps |
| Cytomegalovirus |
| Atypical pneumonia |
| Meningococcemia |
| Staphylococcemia |
| Leishmaniasis |
| Chronic haemolytic anaemias |
| Collagen vascular and autoimmune diseases |
| Systemic lupus erythematosus |
| Rheumatoid arthritis |
| Mixed connective tissue disease |
| Sjögren syndrome |
| Autoimmune multiple endocrine gland insufficiency |
| Autoimmune hypothyroidism |
| Autoimmune chronic hepatitis |
| Drugs and chemicals |
| Pregnancy |
| Severe renal failure |
| Severe nutritional deficiencies (rehabilitation of kwashiorkor) |
| Miscellaneous |
| Post-ABO incompatible bone marrow transplantation |
| Angioimmunoblastic lymphadenopathy |
| Anti-erythropoietin antibodies (spontaneous or post-treatmentwith erythropoietin) |
*Modified with permission from Dessypris and Lipton, 2003.