Table VII.

Complications of pregnancy in women with Diamond Blackfan anaemia (DBA).

Maternal

Increased anaemia with a loss of steroid responsiveness or an increase in transfusion requirement

Accelerated haemochromatosis during respite from chelation

Risk of:

Abortion

Preterm delivery

Pre-eclampsia

Caesarean section

Placental vasculopathy

Fetal

Fetal death

Intra-uterine growth retardation

Prematurity

Recurrence of DBA including severe form, e.g. profound neonatal anaemia and hydrops fetalis

Risk of congenital abnormalities

Data from Faivre et al (2006).