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β-Cell hypertrophy in CTGF+/− adult islets. β-Cell size was measured by labeling for Glut2 (red), which specifically outlines the membranes of β-cells (insulin, green) in both wild type (A) and CTGF heterozygous (B) adults. C, There was a statistically significant increase in average β-cell size in the CTGF heterozygous animals. See Materials and Methods for details regarding measurement of β-cell size. Het, Heterozygous.
