Figure 4.
CTGF mutant animals have an altered islet composition. Morphometric analysis of adult (A), e18.5 (B), and e15.5 (C) insulin and glucagon area. A, Insulin area was unchanged in CTGF+/− adults, whereas glucagon area was increased. At e18.5 (B) and e15.5 (C), insulin area was decreased in CTGF+/− and CTGF−/− pancreata, whereas glucagon area was increased. Animals (n = 5) for each e18.5 genotype, and animals for each e15.5 and adult genotype (n = 3) (see Materials and Methods for full details). Error bars determined by sem. *, P < 0.01 compared with WT. ψ, P < 0.05 compared with CTGF+/− (Student’s t test).