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. 2009 Jan 6;4:1. doi: 10.1186/1750-1326-4-1

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Copyright © 2009 Prasanthi et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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24-OHC increases processing of APP via the non-amyloidogenic pathway. Western blot (a) and densitometric analyses (b) demonstrating increased levels of sAPPα in medium of 24-OHC-treated cells. Treatment with 27-OHC or a mixture of 24-OHC + 27-OHC did not influence sAPPα levels. Levels of Aβ40 were not affected by treatment with 24-OHC, 27-OHC, or a mixture of 24-OHC + 27-OHC compared to levels in control cells (c). *p < 0.05 (One way ANOVA followed by Dunnett's multiple comparison test).