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. Author manuscript; available in PMC: 2009 Mar 12.
Published in final edited form as: Front Biosci. 2009 Jan 1;14:2522–2545. doi: 10.2741/3395

Figure 4.

Figure 4

Schematic diagram of signaling events initiated downstream of ICAM-1 engagement. Leukocyte binding to ICAM-1 triggers diverse signaling pathways within the EC (highlighted in red). Phosphorylation of target proteins (Section 4.1.3.), particularly the VE-cadherin complex (Section 4.1.4.), production of ROS (Section 4.1.5.), activation of Rho family GTPases (Section 4.1.1.), and calcium signaling (Section 4.1.2.) are centrally involved. These pathways all contribute to the junctional disruption and/or actin remodeling that is permissive for leukocyte TEM to occur. (see text for details)