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In vitro receptor binding profile of quetiapine (derived from data of Richelson and Souder 2000)
| Receptor | Mean Kda (nM) |
|---|---|
| α1-adrenergic | 8.1 |
| α2-adrenergic | 80 |
| Dopamine D2 | 770 |
| HistamineH1 | 19 |
| Muscarinergic | 1400 |
| 5HT1A | 300 |
| 5HT2D | 560 |
| 5HT2A | 31 |
| 5HT2C | 3500 |
A lower Kd value indicates higher receptor affinity.
