Table 2.
Quantitative metabolic characteristics of 5,590 and 5,630 treatment-naïve individuals from the population-based Inter99 cohort, stratified according to the PKLR rs3020781 genotype and the NOS1AP rs7538490 genotype, respectively
| PKLR rs3020781 | NOS1AP rs7538490 | |||||||
| TT | TC | CC | pAdd | CC | CT | TT | pDom | |
|
n (men/women) |
3,065 (1,544/1,521) |
2,169 (1,062/1,107) |
356 (180/176) |
2,954 (1,474/1,480) |
2,238 (1,109/1,129) |
438 (221/217) |
||
| Age (years) | 46 ± 8 | 46 ± 8 | 45 ± 8 | 46 ± 8 | 46 ± 8 | 46 ± 8 | ||
| BMI (kg/m2) | 26.2 ± 4.6 | 26.2 ± 4.5 | 25.9 ± 4.3 | 0.58 | 26.2 ± 4.5 | 26.3 ± 4.6 | 26.1 ± 4.6 | 0.52 |
| Plasma glucose (mmol/l) | ||||||||
| Fasting | 5.5 ± 0.8 | 5.6 ± 0.9 | 5.5 ± 0.6 | 0.88 | 5.5 ± 0.7 | 5.5 ± 0.8 | 5.6 ± 1.1 | 0.46 |
| 30-min | 8.7 ± 1.9 | 8.7 ± 1.9 | 8.6 ± 1.9 | 0.31 | 8.7 ± 1.9 | 8.7 ± 1.9 | 8.7 ± 1.8 | 0.90 |
| 120-min | 6.2 ± 2.2 | 6.2 ± 2.1 | 6 ± 2.0 | 0.33 | 6.2 ± 2.1 | 6.2 ± 2.2 | 6.3 ± 2.1 | 0.22 |
| Serum insulin (pmol/l) | ||||||||
| Fasting | 34 (23–50) |
35 (24–52) |
31 (24–47) |
0.21 | 34 (24–51) |
34 (23–51) |
34 (24–51) |
0.14 |
| 30-min | 243 (173–350) |
248 (177–355) |
246 (176–355) |
0.29 | 244 (175–351) |
247 (176–354) |
248 (173–360) |
0.67 |
| 120-min | 154 (93–253) |
161 (99–258) |
150 (91–234) |
0.45 | 155 (95–251) |
157 (97–257) |
158 (103–256) |
0.59 |
| Derived indices | ||||||||
| BIGTT-Si | 9.2 (6.4–12.1) |
9.1 (6.2–11.9) |
9.8 (7.1–12.4) |
0.54 | 9.2 (6.5–12.1) |
9.2 (6.2–12.1) |
9.6 (6.0–12.1) |
0.37 |
| BIGTT-AIR | 1,622 (1,282–2,083) |
1,625 (1,290–2,058) |
1,634 (1,280–2,092) |
0.84 | 1,618 (1,276–2,048) |
1,643 (1,301–2,118) |
1,632 (1,310–2,125) |
0.05 |
| HOMA-IR | 8.2 (5.6–12.6) |
8.5 (5.7–13.4) |
7.7 (5.5–11.4) |
0.24 | 8.3 (5.7–12.9) |
8.4 (5.5–13.1) |
8.0 (5.6–12.6) |
0.14 |
Data are means ± standard deviation or median (interquartile range). Values of plasma glucose, serum insulin, HOMA-IR and BIGTT-AIR were logarithmically transformed before statistical analysis to obtain normal distribution. All analyses of PKLR rs3020781 were made using an additive model (Add), while analyses of NOS1AP rs7539480 were made using a dominant model. Calculated p-values were adjusted for age and sex for BMI measures, for sex, age and BMI for serum insulin, plasma glucose and HOMA-IR, and for age for the BIGTT-Si and BIGTT-AIR index. HOMA-IR was calculated as fasting plasma glucose (mmol/l) multiplied by fasting serum insulin (pmol/l) divided by 22.5. BIGTT-Si and BIGTT-AIR were calculated as described [26].