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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Jun 19;49(11):4953–4960. doi: 10.1167/iovs.08-2217

Figure 8.

Figure 8

Acvr1CKO lens epithelial and fiber cells show increased cell death The percentage of TUNEL-positive nuclei was counted in the different sectors of epithelia and in fiber cells. (A) At E12.5, there was a significant increase in apoptosis in the Acvr1CKO prospective germinative zone (0°-15°) and the prospective transition zone (15°-30°). (B) At E15.5, apoptosis was higher in Acvr1CKO epithelia, particularly in the central region (30°-90°). At E18.5 (C) and P3 (D), apoptosis was significantly higher in the Acvr1CKO transition zone (0°-15°). (E) Acvr1CKO fibers showed increased cell death at all stages. *P < 0.05; ** P < 0.01; ***P < 0.001.