Table 3.
Multivariate Cox Proportional Hazards model of overall survival following diagnosis of muscle-invasive bladder cancer and subsequent radical cystectomy.
| Parameter estimate | Hazard ratio | p-value | ||
|---|---|---|---|---|
| Age | 0.037 | 1.04 | 0.001 | |
| Female gender | −0.090 | 0.91 | 0.50 | |
| Nonwhite race (vs. white) | −0.18 | 0.84 | 0.40 | |
| Married marital status (vs. unmarried) | 0.008 | 1.01 | 0.98 | |
| Charlson comorbidity index (vs. 0-1) | ||||
| 2 | 0.30 | 1.35 | 0.06 | |
| ≥ 3 | 0.71 | 2.03 | 0.017 | |
| Cancer grade (vs. 4) | ||||
| 2 | −0.23 | 0.80 | 0.33 | |
| 3 | −0.022 | 0.98 | 0.89 | |
| US Census region (vs. West) | ||||
| Northeast | 0.073 | 1.08 | 0.66 | |
| South | 0.35 | 1.42 | 0.23 | |
| Midwest | 0.058 | 1.06 | 0.71 | |
| Time to cystectomy (vs. 4-8 weeks) | ||||
| 8-12 weeks | 0.013 | 1.01 | 0.94 | |
| 12-24 weeks | 0.46 | 1.59 | 0.004 | |
| 24 weeks | −3.6 | * | ||
| ≥ 24 weeks * log(delay time) | 0.68 | * | 0.001 | |
*
Hazard ratio for those delayed greater than 24 weeks is a function of time since diagnosis