Figure 5. Examples of splitted SCOP superfamilies with large structural changes.

Above: Two domains classified in SCOP in the metalloproteases superfamily, but splitted in CATH. Their codes are 1c7ka_ (A) and 1e1h.1 (B), with lengths of 132 and 399 residues respectively. Most of the secondary structure elements in the long protein are not matched in the short one. Below: Lambda repressor-like DNA-binding domains 1lmb3_ and 1r69__ (C) and 1d1la_ (D), which represent a well studied example of possible secondary structure switch in evolution.