Figure 1.

Insulin clamp experiments in 5-h-fasted mice. Arterial glucose (A) and GIR (B) during insulin clamps are presented for Glp1r^+/+ (black squares) and Glp1r^−/− (white squares) mice. R_d (C), muscle (gastrocnemius) glycogen (D), endoR_a (E), and liver glycogen (F) from 5-h-fasted (basal, black bars) mice and mice from clamp experiments (insulin clamp, white bars) are presented. Data are mean ± sem for 11–12 mice/genotype. *, P < 0.05 vs. Glp1r^+/+; †, P < 0.05 vs. basal within the same genotype.