Figure 7.

Spontaneous calcium oscillations in GnRH-1 neurons are modulated by PKC. Three representative traces per treatment are shown. A, PMA, an activator of PKC, stimulated calcium spiking in all cells with inhibited GABAergic input by BIC. A similar effect was observed in control cells. B, The stimulatory action of PMA was abolished in all cells bathed in medium containing BSM, a PKC inhibitor. C, BSM treatment lowered the percentage of cells responding to kp-10 to 55%, suggesting a facilitating role of PKC in the kp-10 response.