Table 5.

Effect of major depression on neurotrophin receptors in hippocampus of suicide subjects

Variable	Normal Controls (n=21) 1		Suicide Subjects (n=26)				Overall ANCOVA		Multiple Comparison
	Normal Controls (n=21) 1		With a History of MDD (n=10) 2		With a History of Other Psychiatric Disorders (n=16) 3		F	P	1 VS 2	1 VS 3	2 VS 3

	Mean	SD	Mean	SD	Mean	SD
Phosphorylation^a
TrkA	100	22	60	7	72	14	18.8	<0.001	<0.001	<0.001	0.11
TrkB	100	21	71	19	67	16	13.7	<0.001	0.001	<0.001	0.87
TrkC	100	24	72	22	63	16	13.9	<0.001	0.003	<0.001	0.48
mRNA Levels^b
TrkA	5.1	0.9	2.9	0.6	3.6	0.9	19.7	<0.001	<0.001	<0.001	0.19
TrkC	98.2	20.9	62.2	12.6	58.9	13.1	25.7	<0.001	<0.001	<0.001	0.59
p75NTR	4.4	1.4	7.9	1.5	8.2	1.2	35.3	<0.001	<0.001	<0.001	0.81
Immunolabeling^a
TrkA	100	19	69	18	73	18	10.6	<0.001	0.004	<0.001	0.86
TrkC	100	19	71	13	69	14	19.8	<0.001	<0.001	<0.001	0.67
p75^NTR	100	23	137	23	125	18	8.1	0.001	0.001	0.01	0.16

= percent of control;

= attomoles/μg total RNA.

Data were analyzed using multivariate analysis of covariance (MANCOVA). Overall MANCOVA (Pillai’s Trace test) was found to be statistically significant (F = 3.65, df = 22, 60, P <0.001). The data were then subjected to analysis of covariance (ANCOVA) followed by pairwise between-group comparisons. A total of 11 dependent variables (Activation of TrkA, TrkB, TrkC; mRNA levels of TrkA, TrkC, p75^NTR, NSE, and cyclophilin; and protein levels of TrkA, TrkC, p75^NTR) were considered during multivariate analysis. Age, gender, pH of the brain, race, and postmortem interval were used as covariates. df = 2,39