Table 3.

Relevant gene ontology groups from the analysis of the HDACi data that were identified as significant when using TREAT, but not when using moderated t

Relevant gene ontology groups identified by TREAT, but not moderated t
DNA metabolic process
DNA damage
DNA repair
Response to DNA damage stimulus
Response to endogenous stimulus
Response to stress
Regulation of apoptosis
Regulation of programmed cell death

These are typically key processes in assessing responses to HDACis. Groups were found using a DAVID search from the lists of significantly differentially expressed genes found using the two methods. Ontologies were found to be significant if they had an FDR <5%.