Fig. 5.

Mdr1a.fLUC induction by taxanes. Heterozygous mdr1a^+/fLUC mice were given 10 mg/kg paclitaxel (circles) or 10 mg/kg docetaxel (triangles), as described in Methods. Mice that were injected with saline-diluted Cremophor EL/alcohol (squares) were used as controls. fLUC expression was quantified by measuring luminescence intensity in the abdominal area at various time points before and after drug or vehicle injection. The luminescence intensities recorded from 8 mice were individually normalized to their own luminescence intensities at time 0, before drug or vehicle treatment. Shown are the averages of the normalized values (± SE) at each time point.