Table 2.

Simulation study of observed type I error (%) for general linear models using anti-CCP titer as outcome (Tests N = 1,000,000 random genotypes)

Expected α level
MAF	0.01	0.001	0.0001	0.00001	0.000001
0.01	0.0086	0.00006	0.00007	0.0000160	0.0000008
0.05	0.0097	0.00009	0.00009	0.0000104	0
0.1	0.0098	0.00106	0.00012	0.0000160	0.0000040
0.2	0.0010	0.00096	0.00010	0.0000098	0.0000020
0.3	0.0101	0.00101	0.00011	0.0000093	0.0000021
0.4	0.0099	0.0010	0.00011	0.0000134	0
0.5	0.0100	0.0010	0.00011	0.000014	0