Table 2.

Anamnesis, findings and treatment.

Age	State of disease	Treatment
26	Diagnosis: Left breast cancer, 1.2 cm Histology: moderately differentiated, ductal invasive, Elston-Ellis grade II, estrogen receptor positive, progesterone receptor pos, S-phase impossible to calculate, 2 of 18 axillary lymphnodes positive, no extranodal growth, benign ovaries TNM-classification: pT1 pN1 pM0	Surgery • Local surgery, not radical • Quadrant resection and axillary surgery, radical • Bilateral oophorectomy Radiotherapy: Local 50 Gy, 2 Gy × 25 Hormone therapy: Tamoxifen 20 mg/day, stopped after 4 months due to side effects (bad mood, lower capacity, sensitivity to noise – the symtoms disappeared when therapy was stopped)
34	Onset of severe fatigue
35	Relapse: bone metastasis of breast cancer in sternum, verified by 2 fine-needle biopsies, hormone receptor negative, MIB-1 30%, HER-2 neg. On computer tomography two changes in lungs measuring 6 mm, considered as possible metastasis Complete radiological and clinical remission	Palliative chemotherapy: FEC-60 (Fluorouracil, Epirubicin, Cyclophosphamide) stopped after 5 cycles due to side effects (headache, nausea, pain, anxiety) Radiotherapy: Breast bone 39 Gy, 13 Gy × 3
	Diffuse pain especially in knees	Bisphosphonates, stopped by patient after one month because of lack of improvement
	Reduced fatigue for some months after chemo- and radiotherapy
36	Severe fatigue	10-day rehabilitation in an AM hospital Start of mistletoe treatment
36–38	Fatigue of varying intensity Relapse-free	Mistletoe treatment: Individually adapted dosage and repeated breaks (see text and : Figure 1)