Table 4.
Nephrotoxicity in patients receiving rapid (four hours) or continuous (24 hours) infusion of amphotericin B deoxycholate. Values are median (range) unless stated otherwise
| Infusion rate
|
P value | Median difference (95% CI) | ||
|---|---|---|---|---|
| Rapid (n=40) | Continuous (n=40) | |||
| Serum creatinine concentration (μmol/l): | ||||
| Baseline serum creatinine | 78 (51-128) | 78 (54-165) | ||
| Maximal creatinine:baseline | 1.62 (0.94-3.42) | 1.25 (0.91-2.53) | 0.005 | −0.26 (−0.49 to−0.08) |
| Creatinine at end of study:baseline | 1.55 (0.79-3.42) | 1.17 (0.46-2.26) | 0.001 | −0.32 (−0.53 to −0.13) |
| Calculated creatinine clearance*: | ||||
| Minimal clearance:baseline | 0.62 (0.29-1.05) | 0.80 (0.39-1.10) | 0.013 | 0.12 (0.03 to 0.22) |
| Clearance at end of study:baseline | 0.65 (0.29-1.26) | 0.86 (0.44-1.91) | 0.001 | 0.19 (0.09 to 0.29) |
| Electrolyte abnormalities: | ||||
| No (%) with hypokalaemia (<2.5 mmol/l) | 10 (25) | 4 (10) | ||
| No (%) with hypernatraemia (>155 mmol/l) | 3 (8) | 2 (5) | ||
| No (%) with hypomagnesaemia (<0.5 mmol/l) | 19 (48) | 17 (43) | ||
| Venous bicarbonate concentration† | ||||
| Minimal bicarbonate:baseline | 0.77 (0.44-1.00) | 0.84 (0.59-1.37) | 0.015 | 0.09 (0.02 to 0.17) |
*
Creatinine clearance per 50 kg lean body mass calculated from serum creatinine concentrations.
†
Data missing for eight (rapid infusion) and five (continuous infusion) patients.