Table 2.
Risk phenotypes in the study population and estimated maximum genetic effect on total phenotypic variance for the typed SNPs
| Variable | N | Median (interquartile range) | Maximum genetic effect for typed SNPsa |
|---|---|---|---|
| BMI (kg/m2)b | 1402 | 25.4 (23.1–28.2) | 0.4–1.7% |
| WHR | 1357 | 0.85 (0.78–0.91) | 0.6–1.4% |
| Daytime systolic blood pressure (mmHg)b | 958 | 131 (121.1–144.1) | 0.5–0.7% |
| Mean CIMT (mm)b | 854 | 0.76 (0.65–0.91) | 0.7–1.5% |
| Max CIMT (mm)b | 856 | 0.83 (0.71–1.00) | 0.7–1.4% |
| Plasma total cholesterol (mmol/l)b | 1289 | 5.6 (4.8–6.4) | 0.5–1.4% |
| Plasma IL-6 (pg/ml)b | 1186 | 0.78 (0.48–1.38) | 0.4–0.7% |
| Plasma TNF-α (pg/ml)b | 1186 | 0.74 (0.35–1.66) | 0.6–1.3% |
| Plasma CRP (mg/l)b | 1314 | 1.40 (0.55–3.2) | 0.4–1.7% |
| Plasma Leptin (ng/μl)b | 1319 | 8.6 (4.6–15.3) | 0.5–1.0% |
a
Numbers represent the range of maximum plausible genetic contribution to total phenotypic variance of each trait for typed SNPs.
b
Variables log-transformed before analysis to approximately normalise the distributions.