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. 2009 Mar 23;4(3):e4723. doi: 10.1371/journal.pone.0004723

Table 1. Summary of the effects of AMP-DNM on glycosphingolipid content and blood glucose homeostasis.

	Lean	Lep^Ob	Lep^Ob AMP-DNM	Lean versus Lep^Ob	Lep^Ob versus Lep^Ob AMP-DNM
Glucosylceramide (nmol/ml)	6.20±0.58	12.93±2.08	3.68±0.99	P = 0.0001	P = 0.0022
Ceramide (nmol/ml)	6.77±1.38	15.47±2.93	12.95±3.02	P = 0.0003	n.s.
HbA1C (%)	4.92±0.71	9.64±1.22	5.08±1.06	P<0.0001	P = 0.0006
Blood glucose (millimolar)	10,02±0.45	16.30±3.95	11.58±1.55	P = 0.0077	P = 0.0159
Insulin (ng/ml)	0.72±0.27	19.91±15.44	4.51±0.67	P = 0.024	P = 0.032
HOMA index	6.38±2.45	259.4±173.8	49.71±25.18	P = 0.001	P = 0.0077
OGTT (Area under the curve)	1236±114.2	2266±202.3	1580±33.58	P<0.0001	P = 0.0003

Data are means±S. E. M. Actual P values are indicated and n.s. means no significant difference (n = 5 animals per group).