Figure 1.

Lung histology of wild type (WT) and fat-1 mice before and after induction of acute lung injury (ALI). (A, C, E) Lung histology was performed in WT and (B, D, F) fat-1 mice (A and B) before (0 hours), and (C and D) 24 hours, and (E and F) 72 hours after instillation of 10 μg LPS into the trachea. No difference was found before induction of the injury. After 24 hours, lungs of WT mice displayed a higher amount of amount of leukocytes and interstitial edema as compared with fat-1 mice. Both features were aggravated after 72 hours, with lungs of WT mice still showing a higher degree of interstitial fluid and leukocytes.